Neural tube defects
Supplements studied for neural tube defects.
Overview
Vitamin B9 (Folate) (WA 68; medium effect size, high evidence, high trust) has high-strength evidence for preventing neural tube defects. Research supports folic acid supplementation to reduce these birth defects, with guideline-recommended daily doses for women who can become pregnant and higher doses for those with prior affected pregnancies.
Methionine (WA 40; low effect size, evidence, and trust) has medium-strength observational evidence suggesting higher dietary methionine during pregnancy may be associated with lower neural tube defect risk compared with lower intake.
Folate stands out as the best-supported supplement in this condition. The heatmap and evidence reviews below summarize individual studies.
Effect graph
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Relevant supplements heatmap
Relevant supplements sorted by DEX Score.
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SupplementDEX Database
2 supplements for and rated at least stars. All purchase bands. No minimum star filter.
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Evidence visualised
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