Nonalcoholic steatohepatitis (NASH)
Supplements studied for nonalcoholic steatohepatitis (NASH).
Overview
Evidence for NASH supplements is mostly low-rated. Melatonin (WA 40; low effect size, evidence, and trust) showed improved liver tests and insulin resistance in one small four-week trial. L-Carnitine (WA 52; low effect size, high evidence, medium trust) improved liver markers and weight in two small studies with diet or medications. Milk Thistle (WA 52; low effect size, high evidence, medium trust) has unclear benefit, with inconsistent effects on liver tissue and scarring.
N-Acetyl Cysteine (NAC) (WA 32; very low effect size, low evidence, medium trust) reduced inflammation markers in one pre-surgery study but did not change body size. Whey Protein (WA 36; low effect size, low evidence, very low trust) lowered liver enzymes in one uncontrolled study. The heatmap and evidence reviews below provide trial-level detail.
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SupplementDEX Database
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