Head and Neck Cancer
Supplements studied for head and neck cancer.
Overview
Four supplements are tracked for head and neck cancer (4 studies). Probiotics carry the highest DEX Score (60; medium effect size, medium evidence, high trust). Vitamin E (DEX Score 32; very low effect size, low evidence, medium trust) has low effect-size ratings but medium trust; a large study found high-dose vitamin E did not prevent recurrence and may have increased recurrence risk during and after radiation.
N-Acetyl Cysteine (NAC) and Vitamin A both have DEX Score 32 with very low effect-size ratings but medium-to-high trust from single trials showing no survival or recurrence benefit at high doses. Evidence is limited and, for vitamin E, potentially unfavorable. See the evidence reviews below for details.
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