Canker sores
Supplements studied for canker sores.
Overview
Canker sore supplement evidence is mixed across agents. Aloe products are often similar to standard gels in reviews, though one recent trial found a specific aloe gel outperformed amlexanox and placebo for pain and sore size.
Vitamin B12—both topical ointment and sublingual supplementation—may reduce pain and outbreak frequency in available studies, even when B12 levels are normal. Berberine gel reduced pain and ulcer size versus placebo in one trial. Multivitamins did not prevent sores in a year-long study, and beta-glucan evidence remains uncertain. See the heatmap and evidence reviews below for comparative trial detail.
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SupplementDEX Database
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