Colorectal adenoma
Supplements studied for colorectal adenoma.
Overview
Colorectal adenoma prevention trials highlight mixed folate and B-vitamin findings versus clearer recurrence data for berberine. Folate and combined Vitamin B9 (Folate), Vitamin B6, and Vitamin B12 regimens have not consistently lowered adenoma incidence in large long-term studies of at-risk women.
Berberine 0.3 g twice daily for two years reduced adenoma recurrence by about 22% after polypectomy in Chinese trials. Green Tea extract and Selenium show mixed or subgroup-specific effects depending on sex and prior polyp history. See the heatmap and evidence reviews below.
Effect graph
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SupplementDEX Database
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Evidence visualised
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