Circadian rhythm sleep disorders
Supplements studied for circadian rhythm sleep disorders.
Overview
Vitamin B12 has five trials for circadian rhythm sleep disorders, including delayed sleep phase syndrome, in this review. Supplementation, even when combined with bright light therapy, did not improve sleep-wake timing or related clinical outcomes compared with control conditions in those studies.
Available evidence does not support vitamin B12 for these circadian rhythm sleep problems based on the trials indexed here. No other supplements are listed for this condition in this database. See the evidence reviews below for individual trial detail.
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