Chronic fatigue syndrome (CFS)
Supplements studied for chronic fatigue syndrome (CFS).
Overview
Chronic fatigue syndrome (CFS) supplement trials are small and heterogeneous. NADH (five studies) shows the most repeated signal, with roughly one-third to two-fifths of participants reporting symptom improvement versus lower placebo response rates in short trials; NADH with coenzyme Q10 showed slight gains in fatigue and sleep in one study.
Melatonin results are mixed across small sleep-rhythm studies. Panax Ginseng and Acetyl-L-Carnitine have limited or uncontrolled evidence; Astragalus lacks a detailed summary. See the heatmap and evidence reviews below.
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